Add these to your AV exclusions.
Agent Windows/Configuration
KB0100.60.239.008
Qualifying Conditions : LabTech and Connectwise Automate Versions - All
This article details the specific files and folders to exclude within Antivirus software when using Connectwise Automate.
AV Folder Exclusions:
%windir%\ltsvc
%windir%\temp\ltcache
%windir%\temp\_ltupdate
C:\LTSHARE
C:\ProgramData\MySQL
C:\ProgramFiles\MySQL
C:\Windows\Temp\LTInstall\
C:\Program Files (x86)\LabTech
C:\Program Files (x86)\LabTech Client
AV File Exclusions:
%windir%\ltsvc\lttray.exe
%windir%\ltsvc\ltsvc.exe
%windir%\ltsvc\ltsvcmon.exe